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Using whole genome sequencing data from primary and metastatic sites we inferred the complete chronology of the cancer by exploiting the time of needle tract seeding as an ‘stopwatch’.This approach allowed us to follow the progression of the disease back in time, dating each ancestral node of the phylogenetic tree in the past history of the tumour. I feel compelled to address a maddening trend in the beer universe: Brew-guzzlers’ obsession with extreme freshness when it comes to hoppy beer.A bit o’ back story: Hopped brews, which include the ubiquitous and all-powerful IPA, aren’t supposed to be aged.Patients often ask oncologists how long a cancer has been present before causing symptoms or spreading to other organs.The evolutionary trajectory of cancers can be defined using phylogenetic approaches but lack of chronological references makes dating the exact onset of tumours very challenging.

They say they've found the secret to “long-term chemistry” — what makes a relationship last — in people’s genes.You folks on this fresh train know who you are — and you need to dial it back a few notches.For instance, those hazy, hoppy ales that rule tap handles these days actually taste better with a week or two under their belts.And, if properly stored and served, there’s little discernible change between a two-week old IPA and one that’s been around for six or eight.Brewers also now regularly put “brewed on” or “drink by” dating stamps on hoppy beers, a useful bit of info that, sadly, has had the unintended consequence of fueling the desire for the freshest beer.

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We used a Bayesian phylogenomic approach, which accounts for possible dynamic changes in mutational rate, to reconstruct the phylogenetic tree and effectively ‘carbon date’ the malignant progression.

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